Zoladex 3.6 mg depot
Goserelin, sold under the brand name Zoladex 3.6mg, is a medication that is used to suppress the production of the sex hormones (testosterone and estrogen), particularly in the treatment of breast and prostate cancer. It is an injectable gonadotropin releasing hormone agonist (GnRH agonist). Structurally, it is a decapeptide. It is the natural GnRH decapeptide with two substitutions to inhibit rapid degradation.
Goserelin stimulates the production of the sex hormones testosterone and estrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and estrogen production.
- temporary increase in bone pain
- symptoms of prostatic cancer
- hot flushes
- stomach upset
- difficulty urinating (isolated cases)
- weight gain
- swelling and tenderness of breasts (infrequent)
- decreased erections
- reduced sexual desire