Sibutramine stealth 1104

Active substance: Sibutramine

Popular names: Meridia, Reductil, Sibutramine, Sibutraminum, Siredia, Sibutrex

Active half-life: 1 hour

Sibutramine is an orally administered agent used to produce appetite suppression to attain weight loss in the treatment of patients with obesity. It is a centrally-acting stimulant.

Effects of Sibutramine:

Sibutramine is an orally administered agent for the treatment of obesity. Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. Sibutramine produces its therapeutic effects by inhibition of norepinephrine (NE), serotonin (5-hydroxytryptamine, 5-HT), and to a lesser extent, dopamine reuptake at the neuronal synapse. By inhibiting the reuptake of these neurotransmitters, sibutramine promotes a sense of satiety and a decrease in appetite, thereby reducing food intake. Data from animal studies also suggest that sibutramine may also increase energy expenditure through thermogenic effects in both the basal and fed states, but this has not been confirmed in humans.

Side effects:

• Dry mouth
• nausea
• anorexia
• insomnia
• constipation
• headache
• upset stomach
• menstrual cramps/pain
• flushing
• joint/muscle pain
• high blood pressure

Usage:

Sibutramine is usually taken once daily. Sibutramine can be taken with or without food. It should not be taken for longer than 2 years.

Initial Dose is 10 mg orally once a day, after a period the dose may be increased up to 15 mg.